Anti-TSHZ1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Teashirt zinc finger homeobox 1 is a protein that in humans is encoded by the TSHZ1 gene. This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.
Synonyms
Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F
Gene Name
TSHZ1
Gene ID
10194
UniProt
Q6ZSZ6
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TSHZ1 recombinant protein (Position: K97-R800) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Applications
Flow Cytometry
Field of Research
Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
References & Citations
1. Core, N., Caubit, X., Metchat, A., Boned, A., Djabali, M., Fasano, L. Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev. Biol. 308: 407-420, 2007. 2. Feenstra, I., Vissers, L. E. L. M., Pennings, R. J. E., Nillessen, W., Pfundt, R., Kunst, H. P., Admiraal, R. J., Veltman, J. A., van Ravenswaaij-Arts, C. M. A., Brunner, H. G., Cremers, C. W. R. J. Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans. Am. J. Hum. Genet. 89: 813-819, 2011. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 1/12/2012.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
SET domain bifurcated histone lysine methyltransferase 2
Subcellular Location
Nucleus. Chromosome.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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