Anti-TRMT5 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
TRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine.
Synonyms
Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7
Gene Name
TRMT5
Gene ID
57570
UniProt
Q32P41
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TRMT5 recombinant protein (Position: R291-E501) .
Clonality
Polyclonal
Tissue Specificity
Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .
References & Citations
1. Argente-Escrig, H., Vilchez, J. J., Frasquet, M., Muelas, N., Azorin, I., Vilchez, R., Millet-Sancho, E., Pitarch, I., Tomas-Vila, M., Vazquez-Costa, J. F., Mas-Estelles, F., Marco-Marin, C., Espinos, C., Serrano-Lorenzo, P., Martin, M. A., Lupo, V., Sevilla, T. A novel TRMT5 mutation causes a complex inherited neuropathy syndrome: The role of nerve pathology in defining a demyelinating neuropathy. Neuropath. Appl. Neurobiol. 48: e12817, 2022. 2. Brule, H., Elliott, M., Redlak, M., Zehner, Z. E., Holmes, W. M. Isolation and characterization of the human tRNA- (N (1) G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. Biochemistry 43: 9243-9255, 2004. 3. Haller, R. G., Lewis, S. F., Estabrook, R. W., DiMauro, S., Servidei, S., Foster, D. W. Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency. J. Clin. Invest. 84: 155-161, 1989.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Interleukin 17B
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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