Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-TOMM34 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene. The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.

Synonyms

PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2

Gene Name

TOMM34

Gene ID

10953

UniProt

Q15785

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TOMM34 recombinant protein (Position: M1-H309) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

References & Citations

1. Faou, P., Hoogenraad, N. J. Tom34: a cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import. Biochim. Biophys. Acta 1823: 348-357, 2012. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 10/8/2014. 3. Mukhopadhyay, A., Avramova, L. V., Weiner, H. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. Arch. Biochem. Biophys. 400: 97-104, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Applications Notes

6

Gene Name Synonym

PR/SET domain 5

Subcellular Location

Nucleus.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human TBG (Thyroxine Binding Globulin) ELISA Kit
EK241440 96 Well

Human TBG (Thyroxine Binding Globulin) ELISA Kit

Ask
View Details
Rabbit Anti-Human PAF1 mAb
MA820-01 50 μL

Rabbit Anti-Human PAF1 mAb

Ask
View Details
Rabbit Anti-Human PAF1 mAb
MA820-02 100 μL

Rabbit Anti-Human PAF1 mAb

Ask
View Details
Rat SULT1A1 shRNA Plasmid
abx986852-01 150 µg

Rat SULT1A1 shRNA Plasmid

Ask
View Details
Rat SULT1A1 shRNA Plasmid
abx986852-02 300 µg

Rat SULT1A1 shRNA Plasmid

Ask
View Details
Androsterone glucuronide-d4
HY-151027S-01 500 µg

Androsterone glucuronide-d4

Ask
View Details