Anti-TOM1L1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
TOM1-like protein 1 is a protein that in humans is encoded by the TOM1L1 gene. Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome.
Synonyms
C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16
Gene Name
TOM1L1
Gene ID
10040
UniProt
O75674
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TOM1L1 recombinant protein (Position: D9-D448) .
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
References & Citations
1. Franco, M., Furstoss, O., Simon, V., Benistant, C., Hong, W. J., Roche, S. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Molec. Cell. Biol. 26: 1932-1947, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/12/2012. 3. Katoh, Y., Imakagura, H., Futatsumori, M., Nakayama, K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem. Biophys. Res. Commun. 341: 143-149, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
157578 MW
Applications Notes
6
Gene Name Synonym
C-C motif chemokine ligand 16
Subcellular Location
Secreted.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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