Anti-TOE1 Antibody Picoband® Fluoro647 Conjugated

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene. Enables poly (A) -specific ribonuclease activity and snRNA binding activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Located in Cajal body and cytoplasm. Implicated in pontocerebellar hypoplasia type 7.

Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and inly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

1. Anderson, C., Davies, J. H., Lamont, L., Foulds, N. Early pontocerebellar hypoplasia with vanishing testes: a new syndrome? Am. J. Med. Genet. 155A: 667-672, 2011. 2. Brault, L. S., Cooper, C. A., Famula, T. R., Murray, J. D., Penedo, M. C. T. Mapping of equine cerebellar abiotrophy to ECA2 and identification of a potential causative mutation affecting expression of MUTYH. Genomics 97: 121-129, 2011. 3. de Belle, I., Wu, J.-X., Sperandio, S., Mercola, D., Adamson, E. D. In vivo cloning and characterization of a new growth suppressor protein TOE1 as a target gene of Egr1. J. Biol. Chem. 278: 14306-14312, 2003.