Anti-APRIL/TNFSF13 Antibody Picoband® Fluoro647 Conjugated

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. And this protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

May play a role in spermatogenesis or folliculogenesis (By similarity) . Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

1. Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13. 2. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL et al. (Sep 1998) . APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. The Journal of Experimental Medicine 188 (6) : 1185–90.