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Anti-TM9SF2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Transmembrane 9 superfamily member 2 is a protein that in humans is encoded by the TM9SF2 gene. This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome.

Synonyms

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

Gene Name

TM9SF2

Gene ID

9375

UniProt

Q99805

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human TM9SF2 recombinant protein (Position: R66-S596) .

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Applications

Flow Cytometry

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

References & Citations

1. Diaz, E., Schimmoller, F., Pfeffer, S. R. A novel Rab9 effector required for endosome-to-TGN transport. J. Cell Biol. 138: 283-290, 1997. 2. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014. 3. Schimmoller, F., Diaz, E., Muhlbauer, B., Pfeffer, S. R. Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. Gene 216: 311-318, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64099 MW

Applications Notes

6

Gene Name Synonym

RNA-binding protein 47

Subcellular Location

Nucleus .

Protein Name

Follicular dendritic cell secreted peptide

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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