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Anti-SHCD/SHC4 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane.

Synonyms

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

Gene Name

SHC4

Gene ID

399694

UniProt

Q6S5L8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SHCD/SHC4 recombinant protein (Position: Q57-Q519) .

Clonality

Polyclonal

Tissue Specificity

Brain. Expression restricted to astrocytes.

Applications

Flow Cytometry

Field of Research

Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

References & Citations

1. Ahmed, S. B. M., Prigent, S. A. A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: a potential role for ShcD in the nucleus. Cell. Signal. 26: 32-40, 2014. 2. Fagiani, E., Giardina, G., Luzi, L., Cesaroni, M., Quarto, M., Capra, M., Germano, G., Bono, M., Capillo, M., Pelicci, P., Lanfrancone, L. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. Cancer Res. 67: 3064-3073, 2007. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 02/27/2017.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

29370 MW

Applications Notes

6

Gene Name Synonym

NOVA alternative splicing regulator 2

Subcellular Location

Nucleus.

Protein Name

Aquaporin-6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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