Anti-SERBP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Plasminogen activator inhibitor 1 RNA-binding protein (serbp1) is a protein that in humans is encoded by the SERBP1 gene. Enables SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization. Located in cytosol and nucleus.
Synonyms
C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR-10; G-protein coupled receptor 2; CCR10; GPR2
Gene Name
SERBP1
Gene ID
26135
UniProt
Q8NC51
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SERBP1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 5/29/2014. 2. Heaton, J. H., Dlakic, W. M., Dlakic, M., Gelehrter, T. D. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. J. Biol. Chem. 276: 3341-3347, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
C-C motif chemokine receptor 10
Subcellular Location
Cell membrane, Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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