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Anti-SEL1L Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene. The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5

Gene Name

SEL1L

Gene ID

6400

UniProt

Q9UBV2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SEL1L recombinant protein (Position: E105-E723) .

Clonality

Polyclonal

Tissue Specificity

Testis and brain.

Applications

Flow Cytometry

Field of Research

Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

References & Citations

1. Biunno, I., Appierto, V., Cattaneo, M., Leone, B. E., Balzano, G., Socci, C., Saccone, S., Letizia, A., Valle, G. D., Sgaramella, V. Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. Genomics 46: 284-286, 1997. 2. Cattaneo, M., Canton, C., Albertini, A., Biunno, I. Identification of a region within SEL1L protein required for tumour growth inhibition. Gene 326: 149-156, 2004. 3. Donoviel, D. B., Bernstein, A. SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11. Genomics 56: 232-233, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03343-2-Fluoro647

Applications Notes

6

Gene Name Synonym

Glutathione S-transferase mu 3

Subcellular Location

Cytoplasm.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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