Anti-SEL1L Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene. The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5
Gene Name
SEL1L
Gene ID
6400
UniProt
Q9UBV2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SEL1L recombinant protein (Position: E105-E723) .
Clonality
Polyclonal
Tissue Specificity
Testis and brain.
Applications
Flow Cytometry
Field of Research
Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
References & Citations
1. Biunno, I., Appierto, V., Cattaneo, M., Leone, B. E., Balzano, G., Socci, C., Saccone, S., Letizia, A., Valle, G. D., Sgaramella, V. Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. Genomics 46: 284-286, 1997. 2. Cattaneo, M., Canton, C., Albertini, A., Biunno, I. Identification of a region within SEL1L protein required for tumour growth inhibition. Gene 326: 149-156, 2004. 3. Donoviel, D. B., Bernstein, A. SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11. Genomics 56: 232-233, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Glutathione S-transferase mu 3
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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