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Anti-SDE2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

SDE2

Gene ID

163859

UniProt

Q6IQ49

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SDE2 recombinant protein (Position: I10-K447) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Jess, F. , Anqi, D. , Abigail, M. , Alexandra, M. M. , Neilj, G. , & Daniel, C. , et al. Sde2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Research (16), 16. 2. Rageul, J. , Park, J. J. , Zeng, P. P. , Lee, E. A. , & Kim, H. . Sde2 integrates into the timeless-tipin complex to protect stalled replication forks. Nature Communications. 3. Julie, R. , Park, J. J. , Ukhyun, J. , Weinheimer, A. S. , Vu, T. T. M. , & Hyungjin, K. . (2019) . Conditional degradation of sde2 by the arg/n-end rule pathway regulates stress response at replication forks. Nuclc Acids Research (8), 8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24145 MW

Applications Notes

6

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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