Anti-SCML1 Antibody Picoband® Fluoro647 Conjugated

SCML1 Antibody (8-RY28) is a high quality monoclonal SCML1 antibody (also designated SCML1 antibody) suitable for the detection of the SCML1 protein of human origin. SCML1 Antibody (8-RY28) is available as the non-conjugated anti-SCML1 antibody. Putative Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. SCML1 (sex comb on midleg-like 1 (Drosophila) ), is a 329 amino acid PcG protein belonging to the SCM family. Localizing to nucleus, SCML1 plays a role in testis development, spermatogenesis and embryonal development. While ubiquitously expressed, SCML1 is found at highest levels in adult skeletal muscle, heart and fetal liver. SCML1 contains one SAM (sterile alpha motif) domain and is encoded by a gene that spans 18 kb, contains 6 exons, maps to human chromosome Xp22.13, and is transcribed from telomere to centromere. Three SCML1 isoforms exist as a result of alternative splicing events.

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.

1. van de Vosse, E., Walpole, S. M., Nicolaou, A., van der Bent, P., Cahn, A., Vaudin, M., Ross, M. T., Durham, J., Pavitt, R., Wilkinson, J., Grafham, D., Bergen, A. A. B., van Ommen, G.-J. B., Yates, J. R. W., den Dunnen, J. T., Trump, D. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. Genomics 49: 96-102, 1998.