Anti-SART3 Antibody Picoband®

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene. The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

1. Bell, M., Schreiner, S., Damianov, A., Reddy, R., Bindereif, A. p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. EMBO J. 21: 2724-2735, 2002. 2. De Troyer, L., Zhao, P., Pastor, T., Baietti, M. F., Barra, J., Vendramin, R., Dok, R., Lechat, B., Najm, P., Van Haver, D., Impens, F., Leucci, E., Sablina, A. A. Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3. Nucleic Acids Res. 48: 2502-2517, 2020. Note: Erratum. Nucleic Acids Res. 48: 5198-5199, 2020. 3. Frank, J., van Geel, M., van Steensel, M. A. M. Loss of heterozygosity studies on chromosome 12q in disseminated superficial actinic porokeratosis: lessons to be learned. (Letter) J. Invest. Derm. 127: 2058-2059, 2007.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.