Anti-SAGE1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas.
Synonyms
Transmembrane protein 240; TMEM240; C1orf70
Gene Name
SAGE1
Gene ID
55511
UniProt
Q9NXZ1
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SAGE1 recombinant protein (Position: D94-K633) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
References & Citations
1. Martelange, V., De Smet, C., De Plaen, E., Lurquin, C., Boon, T. Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer Res. 60: 3848-3855, 2000. 2. Ross, M. T., Grafham, D. V., Coffey, A. J., Scherer, S., McLay, K., Muzny, D., Platzer, M., Howell, G. R., Burrows, C., Bird, C. P., Frankish, A., Lovell, F. L., and 270 others. The DNA sequence of the human X chromosome. Nature 434: 325-337, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
19908 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 240
Subcellular Location
Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 240
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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