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Anti-INPP4A Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene. This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.

Synonyms

Ribosome-binding protein 1; 180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor protein; RRBP1; KIAA1398

Gene Name

INPP4A

Gene ID

3631

UniProt

Q96PE3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human INPP4A recombinant protein (Position: Q39-E935) .

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney.

Applications

Flow Cytometry

Field of Research

Cancer, DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, Translation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

References & Citations

1. Joseph, R. E., Walker, J., Norris, F. A. Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. Cytogenet. Cell Genet. 87: 276-277, 1999. 2. Norris, F. A., Auethavekiat, V., Majerus, P. W. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J. Biol. Chem. 270: 16128-16133, 1995. 3. Nystuen, A., Legare, M. E., Shultz, L. D., Frankel, W. N. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 32: 203-212, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Ribosome binding protein 1

Subcellular Location

Endoplasmic reticulum membrane, Single-pass type III membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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