Anti-ACAD9 Antibody Picoband®

Acyl-CoA dehydrogenase family member 9, mitochondrial is an enzyme that in humans is encoded by the ACAD9 gene. This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

1. Dewulf, J. P., Barrea, C., Vincent, M.-F., De Laet, C., Van Coster, R., Seneca, S., Marie, S., Nassogne, M.-C. Evidence of a wide spectrum of cardiac involvement due to ACAD9 mutations: report on nine patients. Molec. Genet. Metab. 118: 185-189, 2016. 2. Ensenauer, R., He, M., Willard, J.-M., Goetzman, E. S., Corydon, T. J., Vandahl, B. B., Mohsen, A.-W., Isaya, G., Vockley, J. Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids. J. Biol. Chem. 280: 32309-32316, 2005. 3. Haack, T. B., Danhauser, K., Haberberger, B., Hoser, J., Strecker, V., Boehm, D., Uziel, G., Lamantea, E., Invernizzi, F., Poulton, J., Rolinski, B., Iuso, A., Biskup, S., Schmidt, T., Mewes, H.-W., Wittig, I., Meitinger, T., Zeviani, M., Prokisch, H. Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency. Nature Genet. 42: 1131-1134, 2010.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.