Anti-TRMT44 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively.
Synonyms
Transmembrane protein 199; TMEM199; C17orf32
Gene Name
TRMT44
Gene ID
152992
UniProt
Q8IYL2
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TRMT44 recombinant protein (Position: M1-S757) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Accessory component of the proton-transporting vacuolar (V) -ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.
References & Citations
1. Leschziner, G. D., Coffey, A. J., Andrew, T., Gregorio, S. P., Dias-Neto, E., Calafato, M., Bentley, D. R., Kinton, L., Sander, J. W., Johnson, M. R. Q81YL2 is a candidate gene for the familial epilepsy syndrome of partial epilepsy with pericentral spikes (PEPS) . Epilepsy Res. 96: 109-115, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
64099 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 199
Subcellular Location
Endoplasmic reticulum membrane. Multi-pass membrane protein. COPI-coated vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein.
Protein Name
DAP3 binding cell death enhancer 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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