What sizes are available for Anti-PCH2/TRIP13 Antibody Picoband® Fluoro647 Conjugated?

Anti-PCH2/TRIP13 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Anti-PCH2/TRIP13 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-PCH2/TRIP13 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-PCH2/TRIP13 Antibody Picoband® Fluoro647 Conjugated is A06921-2-Fluoro647.

Selected Variant

A06921-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

TRIP13 is a mammalian gene that encodes the thyroid receptor-interacting protein 13. This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.

Synonyms

Interleukin-34; IL-34; IL34; C16orf77

Gene Name

TRIP13

Gene ID

9319

UniProt

Q15645

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PCH2/TRIP13 recombinant protein (Position: M1-Q421) .

Clonality

Polyclonal

Tissue Specificity

Detected in the sinusoidal epithelium in the red pulp of spleen. Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

References & Citations

1. Alfieri, C., Chang, L., Barford, D. Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13. Nature 559: 274-278, 2018. 2. Eytan, E., Wang, K., Miniowitz-Shemtov, S., Sitry-Shevah, D., Kaisari, S., Yen, T. J., Liu, S.-T., Hershko, A. Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p13 (comet) . Proc. Nat. Acad. Sci. 111: 12019-12024, 2014. 3. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

87148 MW

Applications Notes

Gene Name Synonym

Interleukin 34

Subcellular Location

Secreted.

Protein Name

ADAM metallopeptidase domain 28

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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