Anti-PCH2/TRIP13 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
TRIP13 is a mammalian gene that encodes the thyroid receptor-interacting protein 13. This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
Synonyms
Interleukin-34; IL-34; IL34; C16orf77
Gene Name
TRIP13
Gene ID
9319
UniProt
Q15645
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PCH2/TRIP13 recombinant protein (Position: M1-Q421) .
Clonality
Polyclonal
Tissue Specificity
Detected in the sinusoidal epithelium in the red pulp of spleen. Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
References & Citations
1. Alfieri, C., Chang, L., Barford, D. Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13. Nature 559: 274-278, 2018. 2. Eytan, E., Wang, K., Miniowitz-Shemtov, S., Sitry-Shevah, D., Kaisari, S., Yen, T. J., Liu, S.-T., Hershko, A. Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p13 (comet) . Proc. Nat. Acad. Sci. 111: 12019-12024, 2014. 3. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
87148 MW
Applications Notes
6
Gene Name Synonym
Interleukin 34
Subcellular Location
Secreted.
Protein Name
ADAM metallopeptidase domain 28
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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