Anti-TREML2 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
TREML2 is a single-pass type I membrane protein, and it contains 1 Ig-like V-type (immunoglobulin-like) domain. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties.
Synonyms
Pannexin-2; PANX2
Gene Name
TREML2
Gene ID
79865
UniProt
Q5T2D2
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TREML2 recombinant protein (Position: E64-I321) .
Clonality
Polyclonal
Tissue Specificity
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Applications
Flow Cytometry
Field of Research
Organelles, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Structural component of the gap junctions and the hemichannels.
References & Citations
1. Allcock, R. J. N., Barrow, A. D., Forbes, S., Beck, S., Trowsdale, J. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Europ. J. Immun. 33: 567-577, 2003. 2. Benitez, B. A., Jin, S. C., Guerreiro, R., Graham, R., Lord, J., Harold, D., Sims, R., Lambert, J.-C., Gibbs, J. R., Bras, J., Sassi, C., Harari, O., and 34 others. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiol. Aging 35: e19-e26, 2014. Note: Electronic Article.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Pannexin 2
Subcellular Location
Cell membrane. Multi-pass membrane protein. Gap junction.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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