Anti-TOX2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
TOX high mobility group box family member 2, also known as TOX2, is a human gene. Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm.
Synonyms
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283
Gene Name
TOX2
Gene ID
84969
UniProt
Q96NM4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TOX2 recombinant protein (Position: Q41-A425) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Kajitani, T., Mizutani, T., Yamada, K., Yazawa, T., Sekiguchi, T., Yoshino, M., Kawata, H., Miyamoto, K. Cloning and characterization of granulosa cell high-mobility group (HMG) -box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Endocrinology 145: 2307-2318, 2004. 2. Scott, A. F. Personal Communication. Baltimore, Md. 7/3/2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
C3 and PZP like, alpha-2-macroglobulin domain containing 8
Subcellular Location
Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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