Anti-TMEM88 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane.
Synonyms
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283
Gene Name
TMEM88
Gene ID
92162
UniProt
Q6PEY1
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TMEM88, which shares 86.7% amino acid (aa) sequence identity with mouse TMEM88.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Lee, H.-J., Finkelstein, D., Li, X., Wu, D., Shi, D.-L., Zheng, J. J. Identification of transmembrane protein 88 (TMEM88) as a Dishevelled-binding protein. J. Biol. Chem. 285: 41549-41556, 2010. 2. Palpant, N. J., Pabon, L., Rabinowitz, J. S., Hadland, B. K., Stoick-Cooper, C. L., Paige, S. L., Bernstein, I. D., Moon, R. T., Murry, C. E. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development 140: 3799-3808, 2013.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
C3 and PZP like, alpha-2-macroglobulin domain containing 8
Subcellular Location
Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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