Anti-TAL1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 is a transcriptionally complex gene that is expressed throughout development, activating or repressing transcription in hematopoietic, neural, and endothelial precursors. This gene is mapped to chromosome 1p33.
Synonyms
T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1; BHLHA17; SCL; TCL5
Gene Name
TAL1
Gene ID
6886
UniProt
P17542
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TAL1, which shares 82.4% amino acid (aa) sequence identity with mouse and rat TAL1.
Clonality
Polyclonal
Tissue Specificity
Leukemic stem cell.
Applications
Flow Cytometry
Field of Research
Cell Differentiation, Developmental Biology, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Organogenesis, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) .
References & Citations
1. Hosur, V., Cox, M. L., Burzenski, L. M., Riding, R. L., Alley, L., Lyons, B. L., Kavirayani, A., Martin, K. A., Cox, G. A., Johnson, K. R., Shultz, L. D. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in hairpatches (Hpt) mice. PLoS One 8: e53426, 2013. Note: Electronic Article. 2. Hu, X., Li, X., Valverde, K., Fu, X., Noguchi, C., Qiu, Y., Huang, S. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50408 MW
Applications Notes
6
Gene Name Synonym
TAL bHLH transcription factor 1, erythroid differentiation factor
Subcellular Location
Nucleus.
Protein Name
Protein C-ets-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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