Anti-gamma Synuclein/SNCG Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development.
Synonyms
Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-laminin subunit gamma; S-LAM gamma; Lamc1; Lamb-2, Lamc-1
Gene Name
SNCG
Gene ID
6623
UniProt
O76070
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human gamma Synuclein/SNCG, which shares 53.8% amino acid (aa) sequence identity with rat SNCG.
Clonality
Polyclonal
Tissue Specificity
Found in the basement membranes (major component) .
Applications
Flow Cytometry
Field of Research
Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
References & Citations
1. Ji, H., Liu, Y. E., Jia, T., Wang, M., Liu, J., Xiao, G., Joseph, B. K., Rosen, C., Shi, Y. E. Identification of a breast cancer-specific gene, BCSG1, by differential cDNA sequencing. Cancer Res. 57: 759-764, 1997. 2. Lavedan, C., Buchholtz, S., Auburger, G., Albin, R. L., Athanassiadou, A., Blancato, J., Burguera, J. A., Ferrell, R. E., Kostic, V., Leroy, E., Leube, B., Mota-Vieira, L., and 9 others. Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998. 3. Lavedan, C., Leroy, E., Dehejia, A., Buchholtz, S., Dutra, A., Nussbaum, R. L., Polymeropoulos, M. H. Identification, localization and characterization of the human gamma-synuclein gene. Hum. Genet. 103: 106-112, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
177298 MW
Applications Notes
6
Gene Name Synonym
Laminin subunit gamma-1
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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