Anti-ZMYND8 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene. The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms
Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; IFT88; TG737; TTC10
Gene Name
ZMYND8
Gene ID
23613
UniProt
Q9ULU4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ZMYND8 recombinant protein (Position: M1-Q1087) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, ECM Proteins, Neuroscience
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
References & Citations
1. Fossey, S. C., Kuroda, S., Price, J. A., Pendleton, J. K., Freedman, B. I., Bowden, D. W. Identification and characterization of PRKCBP1, a candidate RACK-like protein. Mammalian Genome 11: 919-925, 2000. 2. Gross, M. B. Personal Communication. Baltimore, Md. 3/28/2014. 3. Shen, H., Xu, W., Guo, R., Rong, B., Gu, L., Wang, Z., He, C., Zheng, L., Hu, X., Hu, Z., Shao, Z.-M., Yang, P., Wu, F., Shi, Y. G., Shi, Y., Lan, F. Suppression of enhancer overactivation by a RACK7-histone demethylase complex. Cell 165: 331-342, 2016.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Intraflagellar transport 88
Subcellular Location
Centriole. Cilium basal body. Centrosome. Cilium. Cytoplasm. Flagellum.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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