Anti-WIPF3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Predicted to enable SH3 domain binding activity and actin binding activity. Predicted to be involved in actin filament-based movement. Predicted to be located in cytosol. Predicted to be active in actin filament.
Synonyms
Transmembrane protein 240; TMEM240; C1orf70
Gene Name
WIPF3
Gene ID
644150
UniProt
A6NGB9
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human WIPF3, which shares 95.5% and 90.9% amino acid (aa) sequence identity with mouse and rat WIPF3, respectively.
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 11/21/2008. 2. Ho, H.-Y. H., Rohatgi, R., Ma, L., Kirschner, M. W. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proc. Nat. Acad. Sci. 98: 11306-11311, 2001. 3. Masters, J. N., Cotman, S. L., Osterburg, H. H., Nichols, N. R., Finch, C. E. Modulation of a novel RNA in brain neurons by glucocorticoid and mineralocorticoid receptors. Neuroendocrinology 63: 28-38, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
19908 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 240
Subcellular Location
Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 240
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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