Anti-FFR/VPS51 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants.
Synonyms
PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; PHF21A; BHC80; KIAA1696; BM-006
Gene Name
VPS51
Gene ID
738
UniProt
Q9UID3
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human FFR/VPS51 recombinant protein (Position: K38-R781) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in brain. Expressed at much lower level in other tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
References & Citations
1. Gershlick, D. C., Ishida, M., Jones, J. R., Bellomo, A., Bonifacino, J. S., Everman, D. B. A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes. Hum. Molec. Genet. 28: 1548-1560, 2019. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 4/14/2014. 3. Perez-Victoria, F. J., Schindler, C., Magadan, J. G., Mardones, G. A., Delevoye, C., Romao, M., Raposo, G., Bonifacino, J. S. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. Molec. Biol. Cell 21: 3386-3395, 2010.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
PHD finger protein 21A
Subcellular Location
Nucleus.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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