Anti-TMEM97 Antibody Picoband®

Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

1. Bartz, F., Kern, L., Erz, D., Zhu, M., Gilbert, D., Meinhof, T., Wirkner, U., Erfle, H., Muckenthaler, M., Pepperkok, R., Runz, H. Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab. 10: 63-75, 2009. 2. Kayed, H., Kleeff, J., Ding, J., Hammer, J., Giese, T., Zentgraf, H., Buchler, M. W., Friess, H. Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract. Histol. Histopath. 19: 1021-1031, 2004. 3. Malhotra, K., Luehrsen, K. R., Costello, L. L., Raich, T. J., Sim, K., Foltz, L., Davidson, S., Xu, H., Chen, A., Yamanishi, D. T., Lindemann, G. W., Cain, C. A., Madlansacay, M. R., Hashima, S. M., Pham, T. L., Mahoney, W., Schueler, P. A. Identification of differentially expressed mRNAs in human fetal liver across gestation. Nucleic Acids Res. 27: 839-847, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.