Anti-TIM 4/TIMD4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.
Synonyms
Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; Gp2
Gene Name
TIMD4
Gene ID
91937
UniProt
Q96H15
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TIM 4/TIMD4 recombinant protein (Position: S24-L378) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.
Applications
Flow Cytometry
Field of Research
Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
References & Citations
1. Czuczman, M. A., Fattouh, R., van Rijn, J. M., Canadien, V., Osborne, S., Muise, A. M., Kuchroo, V. K., Higgins, D. E., Brumell, J. H. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature 509: 230-234, 2014. 2. Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., Freeman, G. J. The TIM gene family: emerging roles in immunity and disease. Nature Rev. Immun. 3: 454-462, 2003. 3. Meyers, J. H., Chakravarti, S., Schlesinger, D., Illes, Z., Waldner, H., Umetsu, S. E., Kenny, J., Zheng, X. X., Umetsu, D. T., DeKruyff, R. H., Strom, T. B., Kuchroo, V. K. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nature Immun. 6: 455-464, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Glycoprotein 2 (zymogen granule membrane)
Subcellular Location
Cell membrane. GPI-anchor. Secreted.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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