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Anti-MAT1A Antibody Picoband®

Boster Bio Anti-MAT1A Antibody Picoband® catalog # A04203-1. Tested in WB, ICC/IF, Flow Cytometry (applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

Synonyms

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

Gene Name

MAT1A

Gene ID

4143

UniProt

Q00266

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human MAT1A, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Applications

WB, ICC/IF, Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

References & Citations

1. Alvarez, L., Corrales, F., Martin-Duce, A., Mato, J. M. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem. J. 293: 481-486, 1993. 2. Blom, H. J., Davidson, A. J., Finkelstein, J. D., Luder, A. S., Bernardini, I., Martin, J. J., Tangerman, A., Trijbels, J. M. F., Mudd, S. H., Goodman, S. I., Gahl, W. A. Persistent hypermethioninaemia with dominant inheritance. J. Inherit. Metab. Dis. 15: 188-197, 1992. 3. Cabrero, C., Puerta, J., Alemany, S. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Europ. J. Biochem. 170: 299-304, 1987.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

44 kDa

Observed Molecular Weight

50 kDa

Applications Notes

6

Gene Name Synonym

Transforming acidic coiled-coil-containing protein 1

Subcellular Location

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Protein Name

Transforming acidic coiled-coil-containing protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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