What sizes are available for Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated?

Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated is A15490-1-Fluoro488.

Q: Is Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated in stock?

Anti-HOXC12 Antibody Picoband® Fluoro488 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Selected Variant

A15490-1-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

HOXC12

Gene ID

3228

UniProt

P31275

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human HOXC12 recombinant protein (Position: M1-N195) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Kang, X. , Qi, Y. , Yong, Z. , Qi, W. , & Yeh, E. . (2010) . Sumo-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Molecular Cell, 38 (2), 191-201. 2. Grier, D. G. , Thompson, A. , Lappin, T. , & Halliday, H. L. . (2009) . Quantification of hox and surfactant protein-b transcription during murine lung development. Neonatology, 96 (1), 50-60. 3. Katayama, K. , Furuno, A. , Akiyama, K. , Tsuji, T. , & Kunieda, T. . (2007) . Characterization of chromosomal inversion of the mouse hairy ears (eh) mutation associated with cleft palate. Mammalian Genome, 18 (4), 246-254.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24145 MW

Applications Notes

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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