Anti-VRK2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity.
Synonyms
NACHT, LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; NLRP2; NALP2; NBS1; PAN1; PYPAF2
Gene Name
VRK2
Gene ID
7444
UniProt
Q86Y07
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human VRK2 recombinant protein (Position: K19-R491) .
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
Applications
Flow Cytometry
Field of Research
Apoptosis, Caspases, Cell Biology, Intracellular
Purification
Immunogen affinity purified.
Form
Liquid
Function
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
References & Citations
1. Nezu, J., Oku, A., Jones, M. H., Shimane, M. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45: 327-331, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
NLR family pyrin domain containing 2
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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