Anti-Hox8/MSX2 Antibody Picoband® Fluoro594 Conjugated

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E) -farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; Fdps

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

1. Bernardini, L., Castori, M., Capalbo, A., Mokini, V., Mingarelli, R., Simi, P., Bertuccelli, A., Novelli, A., Dallapiccola, B. Syndromic craniosynostosis due to complex chromosome 5 rearrangement and MSX2 gene triplication. Am. J. Med. Genet. 143A: 2937-2943, 2007. 2. Davidson, D. The function and evolution of Msx genes: pointers and paradoxes. Trends Genet. 11: 405-411, 1995. 3. Florisson, J. M. G., Verkerk, A. J. M. H., Huigh, D., Hoogeboom, A. J. M., Swagemakers, S., Kremer, A., Heijsman, D., Lequin, M. H., Mathijssen, I. M. J., van der Spek, P. J. Boston type craniosynostosis: report of a second mutation in MSX2. Am. J. Med. Genet. 161A: 2626-2633, 2013.