Anti-IRF7 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses.
Synonyms
GTPase HRas; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras; GTPase HRas, N-terminally processed; HRAS; HRAS1
Gene Name
IRF7
Gene ID
3665
UniProt
Q92985
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human IRF7 recombinant protein (Position: Y27-A503) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. .
Applications
Flow Cytometry
Field of Research
Associated Proteins, Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling, G Protein Signaling, Intracellular, Nucleotide Messenger, Proto-Oncogenes, Ras Family, Second Messenger, Signal Transduction, Signaling Pathway, Small G Proteins, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. .
References & Citations
1. Au, W.-C., Moore, P. A., LaFleur, D. W., Tombal, B., Pitha, P. M. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J. Biol. Chem. 273: 29210-29217, 1998. 2. Au, W.-C., Yeow, W.-S., Pitha, P. M. Analysis of functional domain of interferon regulatory factor 7 and its association with IRF-3. Virology 280: 273-282, 2001. 3. Chen, H.-W., King, K., Tu, J., Sanchez, M., Luster, A. D., Shresta, S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against Dengue virus. J. Immun. 191: 4194-4201, 2013.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
21298 MW
Applications Notes
6
Gene Name Synonym
GTPase HRas
Subcellular Location
Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity) . Shuttles between the plasma membrane and the Golgi apparatus. .
Protein Name
GTPase Hras
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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