Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Granzyme K/GZMK Antibody

Boster Bio Anti-Granzyme K/GZMK Antibody Picoband® catalog # A06281-2. Tested in IHC applications. This antibody reacts with Human.

Product Specifications

Background

Granzyme K is a protein that in humans is encoded by the GZMK gene. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes

Synonyms

ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1; ELAVL2; HUB

Gene Name

GZMK

Gene ID

3003

UniProt

P49863

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Granzyme K/GZMK, which shares 71.4% and 73.9% amino acid (aa) sequence identity with mouse and rat GZMK, respectively.

Clonality

Polyclonal

Tissue Specificity

Brain; neural-specific.

Applications

IHC

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.

References & Citations

1. Baker, E., Sayers, T. J., Sutherland, G. R., Smyth, M. J. The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. Immunogenetics 40: 235-237, 1994. 2. Przetak, M. M., Yoast, S., Schmidt, B. F. Cloning of cDNA for human granzyme 3. FEBS Lett. 364: 268-271, 1995. 3. Sayers, T. J., Lloyd, A. R., McVicar, D. W., O'Connor, M. D., Kelly, J. M., Carter, C. R. D., Wiltrout, T. A., Wiltrout, R. H., Smyth, M. J. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. J. Leuko. Biol. 59: 763-768, 1996.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

49655 MW

Observed Molecular Weight

41 kDa

Gene Name Synonym

ELAV like RNA binding protein 2

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm.

Protein Name

AP-2 complex subunit mu

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit
abx585373-01 96 Tests

Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit

Ask
View Details
Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit
abx585373-02 5x 96 Tests

Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit

Ask
View Details
Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit
abx585373-03 10x 96 Tests

Rat Phosphofructokinase, Platelet (PFKP) ELISA Kit

Ask
View Details
1600015I10Rik (NM_001081273) Mouse Tagged ORF Clone
MG214065 10 µg

1600015I10Rik (NM_001081273) Mouse Tagged ORF Clone

Ask
View Details
Human CAMK1G ELISA KIT
ELI-44155h 96 Tests

Human CAMK1G ELISA KIT

Ask
View Details
Atp9b (NM_015805) Mouse Tagged Lenti ORF Clone
MR219281L4 10 µg

Atp9b (NM_015805) Mouse Tagged Lenti ORF Clone

Ask
View Details