Anti-B3GNT2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene.
Synonyms
Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP; MED20; TRFP
Gene Name
B3GNT2
Gene ID
10678
UniProt
Q9NY97
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human B3GNT2 recombinant protein (Position: R6-C397) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Mediator Complex, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Bischoff, J. R., Plowman, G. D. The Aurora/lpl 1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9: 454-459, 1999. 2. Du, J., Jablonski, S., Yen, T. J., Hannon, G. J. Astrin regulates Aurora-A localization. Biochem. Biophys. Res. Commun. 370: 213-219, 2008. 3. Ewart-Toland, A., Briassouli, P., de Koning, J. P., Mao, J.-H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B. A. J., Nagase, H., Burn, J., Ball, S., Almeida, M., Linardopoulos, S., Balmain, A. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nature Genet. 34: 403-412, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Nucleus .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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