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Anti-NRBF2 Antibody Picoband® Fluoro550 Conjugated

Selected Variant

A09144-2-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene. Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III.

Synonyms

Tudor domain-containing protein 3; TDRD3

Gene Name

NRBF2

Gene ID

29982

UniProt

Q96F24

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NRBF2 recombinant protein (Position: M1-N287) .

Clonality

Polyclonal

Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Immunoglobulins, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

References & Citations

1. Darabi, H., McCue, K., Beesley, J., Michailidou, K., Nord, S., Kar, S., Humphreys, K., Thompson, D., Ghoussaini, M., Bolla, M. K., Dennis, J., Wang, Q., and 119 others. Polymorphisms in a putative enhancer at the 10q21.2 breast cancer risk locus regulate NRBF2 expression. Am. J. Hum. Genet. 97: 22-34, 2015. 2. Flores, A. M., Li, L., Aneskievich, B. J. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. J. Invest. Derm. 123: 1092-1101, 2004. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 7/22/2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Tudor domain containing 3

Subcellular Location

Nucleus. Cytoplasm.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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