Anti-IKB epsilon/Nfkbie Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene. Predicted to be involved in D-serine transport. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; genitourinary system; and thymus. Orthologous to human NFKBIE (NFKB inhibitor epsilon) .
Synonyms
Mimecan; Osteoglycin; Ogn; Og
Gene Name
Nfkbie
Gene ID
18037
UniProt
O54910
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse IKB epsilon/Nfkbie recombinant protein (Position: Q111-D364) .
Clonality
Polyclonal
Tissue Specificity
Expressed in kidney.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures
Purification
Immunogen affinity purified.
Form
Liquid
Function
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
References & Citations
1. Hoffmann, A., Levchenko, A., Scott, M. L., Baltimore, D. The I-kappa-B-NF-kappa-B signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002. Note: Erratum: Science 318: 1550 only, 2007. 2. Li, Z., Nabel, G. J. A new member of the I-kappa-B protein family, I-kappa-B epsilon, inhibits RelA (p65) -mediated NF-kappa-B transcription. Molec. Cell. Biol. 17: 6184-6190, 1997. 3. Ting, A. Y., Endy, D. Decoding NF-kappa-B signaling. Science 298: 1189-1190, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Osteoglycin
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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