Anti-IMPDH2 Antibody Picoband® Fluoro647 Conjugated

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures. Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths. Detected in compact myelin (at protein level) . Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity) . Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity) . Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity) . Inhibits axon outgrowth by binding to RTN4R (By similarity) . Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity) .

1. Glesne, D. A., Huberman, E. Cloning and sequencing of the human type II IMP dehydrogenase gene. Biochem. Biophys. Res. Commun. 205: 537-544, 1994. 2. Glesne, D., Collart, F., Varkony, T., Drabkin, H., Huberman, E. Chromosomal localization and structure of the human type II IMP dehydrogenase gene (IMPDH2) . Genomics 16: 274-277, 1993. 3. Kost-Alimova, M. V., Glesne, D. A., Huberman, E., Zelenin, A. V. Assignment of inosine 5-prime-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. Cytogenet. Cell Genet. 82: 145-146, 1998.