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Anti-HDAC1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A00256-4-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Furukawa et al. (1996) mapped RPD3L1 to 1p34.1 by fluorescence in situ hybridization.

Synonyms

Angiotensin-converting enzyme; ACE; Dipeptidyl carboxypeptidase I; Kininase II; CD143; Angiotensin-converting enzyme, soluble form; Ace; Dcp1

Gene Name

HDAC1

Gene ID

3065

UniProt

Q13547

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human HDAC1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Testis-specific isoform is expressed in spermatocytes, adult testis.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Metabolism Processes, Metalloprotease, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Serum Proteins, Signal Transduction, Stem Cells, Surface Molecules, Vasculature, Vitamins/Minerals

Purification

Immunogen affinity purified.

Form

Liquid

Function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

References & Citations

1. Taunton J, Hassig CA, Schreiber SL (May 1996) . A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Subcellular Location

Angiotensin-converting enzyme, soluble form: Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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