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Anti-Calnexin/CANX Antibody Picoband® (monoclonal, 8D10B3) Fluoro488 Conjugated

Selected Variant

M03372-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Calnexin (CNX) is a 67 kDa integral protein of the endoplasmic reticulum. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER) -associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms

Cadherin-3; Placental cadherin; P-cadherin; CDH3; CDHP

Gene Name

CANX

Gene ID

821

UniProt

P27824

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Calnexin/CANX recombinant protein (Position: E68-R582) .

Clonality

Monoclonal

Clone

Clone: 8D10B3

Tissue Specificity

Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Applications

Flow Cytometry

Field of Research

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

References & Citations

1. Denzel, A., Molinari, M., Trigueros, C., Martin, J. E., Velmurgan, S., Brown, S., Stamp, G., Owen, M. J. Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Molec. Cell. Biol. 22: 7398-7404, 2002. 2. Dickson, K. M., Bergeron, J. J. M., Shames, I., Colby, J., Nguyen, D. T., Chevet, E., Thomas, D. Y., Snipes, G. J. Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for 'gain-of-function' ER diseases. Proc. Nat. Acad. Sci. 99: 9852-9857, 2002. 3. Gray, P. W., Byers, M. G., Eddy, R. L., Shows, T. B. The assignment of the calnexin gene to the q35 region of chromosome 5. (Abstract) Human Genome Mapping Workshop 93, Kobe, Japan 1993. P. 9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Cadherin 3, type 1, P-cadherin (placental)

Subcellular Location

Cell membrane. Single-pass type I membrane protein.

Protein Name

High mobility group protein B3

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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