Anti-TIP49A/RUVBL1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene. This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants.
Synonyms
G2/mitotic-specific cyclin-B2; CCNB2
Gene Name
RUVBL1
Gene ID
8607
UniProt
Q9Y265
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TIP49A/RUVBL1 recombinant protein (Position: Q13-D23) .
Clonality
Polyclonal
Tissue Specificity
Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
References & Citations
1. Bauer, A., Huber, O., Kemler, R. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. Proc. Nat. Acad. Sci. 95: 14787-14792, 1998. 2. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., Cote, J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Molec. Cell. Biol. 24: 1884-1896, 2004. 3. Fazzio, T. G., Huff, J. T., Panning, B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134: 162-174, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
37492 MW
Applications Notes
6
Gene Name Synonym
Cyclin B2
Subcellular Location
Centrosome. Microtubule cytoskeleton. Cytosol. Nucleus. Cyclin-dependent protein kinase holoenzyme complex. Cytoplasm. Membrane.
Protein Name
G2/mitotic-specific cyclin-B2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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