Anti-RRS1 Antibody Picoband®

Ribosome biogenesis regulatory protein homolog is a protein that in humans is encoded by the RRS1 gene. RRS1 involved in ribosomal large subunit assembly and may regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; TNFSF18; AITRL, GITRL, TL6; UNQ149/PRO175

A synthetic peptide corresponding to a sequence at the C-terminus of human RRS1, which shares 95.5% and 100% amino acid (aa) sequence identity with mouse and rat RRS1, respectively.

Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569) . Promotes leukocyte adhesion to endothelial cells (PubMed:23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity) .

1. Gambe, A. E., Matsunaga, S., Takata, H., Ono-Maniwa, R., Baba, A., Uchiyama, S., Fukui, K. A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583: 1951-1956, 2009. 2. Gross, M. B. Personal Communication. Baltimore, Md. 1/31/2019. 3. Tsuno, A., Miyoshi, K., Tsujii, R., Miyakawa, T., Mizuta, K. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Molec. Cell. Biol. 20: 2066-2074, 2000.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.