Anti-NOP58 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nucleolar protein 58 is a protein that in humans is encoded by the NOP58 gene. The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs.
Synonyms
Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2
Gene Name
NOP58
Gene ID
51602
UniProt
Q9Y2X3
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NOP58 recombinant protein (Position: K30-K450) .
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/8/2016. 2. Lyman, S. K., Gerace, L., Baserga, S. J. Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins. RNA 5: 1597-1604, 1999. 3. Nelson, S. A., Santora, K. E., LaRochelle, W. J. Isolation and characterization of a novel PDGF-induced human gene. Gene 253: 87-93, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39125 MW
Applications Notes
6
Gene Name Synonym
Matrix metallopeptidase 16
Subcellular Location
Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.
Protein Name
RNA-binding protein Musashi homolog 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1062112-01 0.02 mg (E-Coli)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details 
MBS1062112-02 0.1 mg (E-Coli)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details MBS1062112-03 0.02 mg (Baculovirus)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details 
MBS1062112-04 0.02 mg (Mammalian-Cell)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details MBS1062112-05 1 mg (E-Coli)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details MBS1062112-06 0.1 mg (Baculovirus)
Recombinant Listeria welshimeri serovar 6b Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details