Anti-TOMM20 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondrial outer membrane.
Synonyms
Homeobox protein Hox-A5; Homeobox protein Hox-1C; HOXA5; HOX1C
Gene Name
TOMM20
Gene ID
9804
UniProt
Q15388
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TOMM20 recombinant protein (Position: D25-E145) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636) . Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636) . Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Cycle, Cell Cycle Inhibitors, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, p53 Pathway, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
References & Citations
1. Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S., Endo, T., Kohda, D. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100: 551-560, 2000. 2. Blesa, J. R., Prieto-Ruiz, J. A., Hernandez, J. M., Hernandez-Yago, J. NRF-2 transcription factor is required for human TOMM20 gene expression. Gene 391: 198-208, 2007. 3. Goping, I. S., Millar, D. G., Shore, G. C. Identification of the human mitochondrial protein import receptor, huMas20p: complementation of delta-mas20 in yeast. FEBS Lett. 373: 45-50, 1995.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
16 kDa
Applications Notes
6
Gene Name Synonym
Homeobox A5
Subcellular Location
Nucleus.
Protein Name
Ran-specific GTPase-activating protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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