Anti-RING2/RING1B/RNF2 Antibody Picoband® Fluoro488 Conjugated

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene. Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2) . Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

1. Entrez Gene: RNF2 ring finger protein 2. 2. Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001) . E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. FEBS Lett 503 (1) : 61–4. 3. Tuckfield, Annabel; Clouston David R; Wilanowski Tomasz M; Zhao Lin-Lin; Cunningham John M; Jane Stephen M (March 2002) . Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. Mol. Cell. Biol. (United States) 22 (6) : 1936–46.