Anti-NDFIP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.
Synonyms
Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter; SLC12A5; KCC2; KIAA1176
Gene Name
NDFIP1
Gene ID
80762
UniProt
Q9BT67
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NDFIP1 recombinant protein (Position: A10-Y221) .
Clonality
Polyclonal
Tissue Specificity
Brain specific. Detected in neuronal cells.
Applications
Flow Cytometry
Field of Research
Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels
Purification
Immunogen affinity purified.
Form
Liquid
Function
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
References & Citations
1. Foot, N. J., Leong, Y. A., Dorstyn, L. E., Dalton, H. E., Ho, K., Zhao, L., Garrick, M. D., Yang, B., Hiwase, D., Kumar, S. Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood 117: 638-646, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 6/11/2008. 3. Harvey, K. F., Shearwin-Whyatt, L. M., Fotia, A., Parton, R. G., Kumar, S. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J. Biol. Chem. 277: 9307-9317, 2002
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Solute carrier family 12 member 5
Subcellular Location
Membrane. Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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