Anti-MX1 Antibody Picoband® Fluoro488 Conjugated

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. This gene encodes a guanosine triphosphate (GTP) -metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.

Angiogenesis, Cancer, Cardiovascular, Developmental Biology, Embryogenesis, Growth Factors, Growth Factors/Hormones, Lineage Specification, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

1. Bigham, A. W., Buckingham, K. J., Husain, S., Emond, M. J., Bofferding, K. M., Gildersleeve, H., Rutherford, A., Astakhova, N. M., Perelygin, A. A., Busch, M. P., Murray, K. O., Sejvar, J. J., Green, S., Kriesel, J., Brinton, M. A., Bamshad, M. Host genetic risk factors for West Nile virus infection and disease progression. PLoS One 6: e24745, 2011. Note: Electronic Article. 2. Horisberger, M. A., Wathelet, M., Szpirer, J., Szpirer, C., Islam, Q., Levan, G., Huez, G., Content, J. cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene. Somat. Cell Molec. Genet. 14: 123-131, 1988. 3. Huber, P., Aebi, M., Grob, R., Pravtcheva, D., Ruddle, F., Haller, O. Chromosomal localization of two human Mx genes. (Abstract) Experientia 44: A84 only, 1988.