Anti-GRASP1/GRIPAP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene. This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) . The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function.
Synonyms
Alpha-amylase 1;3.2.1.1;1,4-alpha-D-glucan glucanohydrolase 1; Salivary alpha-amylase; AMY1A; AMY1; AMY1B; AMY1; AMY1C; AMY1
Gene Name
GRIPAP1
Gene ID
56850
UniProt
Q4V328
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human GRASP1/GRIPAP1 recombinant protein (Position: R42-S841) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 2/17/2015. 2. Hirosawa, M., Nagase, T., Ishikawa, K., Kikuno, R., Nomura, N., Ohara, O. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6: 329-336, 1999. 3. Stinton, L. M., Selak, S., Fritzler, M. J. Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. Clin. Immun. 116: 108-117, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
57768 MW
Applications Notes
6
Gene Name Synonym
Alpha-amylase 1
Subcellular Location
Secreted.
Protein Name
Alpha-amylase 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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